Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type	Study_count
Total_Studies	1677
interventional	1052
Observational	510
Registry	115

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Device	252
Drug	219
Procedure	205
Other	95
Drug\|placebo	85
Behavioral	48
Device\|Drug	23
Drug\|Procedure	22
Device\|Procedure	18
Device\|Other	14
Diagnostic Test	14
Drug\|Other	11
Behavioral\|Other	7
Other\|Procedure	7
Device\|Drug\|Procedure	5
Behavioral\|Device	3
Diagnostic Test\|Other	2
Dietary Supplement	2
Dietary Supplement\|placebo	2
Drug\|Other\|Procedure	2
Drug\|placebo\|Procedure	2
Genetic	2
Behavioral\|Drug	1
Behavioral\|Genetic	1
Biological	1
Biological\|Device	1
Biological\|placebo	1
Combination Product	1
Device\|Drug\|Other	1
Device\|Other\|Procedure	1
Dietary Supplement\|Drug\|Other	1
Drug\|Genetic	1
Drug\|Other\|placebo	1
placebo\|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country	Study_Count
United States	252
Canada	77
Germany	50
United Kingdom	47
NA	45
Korea, Republic of	41
France	35
China	34
Denmark	27
Italy	25
Netherlands	22
Japan	20
Spain	20
Russian Federation	17
United States\|Canada	17
Norway	14
Sweden	14
Belgium	11
Brazil	8
Czechia	7
Finland	7
Switzerland	7
Israel	6
Poland	6
Taiwan	6
Austria	5
Australia	4
Czechia\|France	4
Egypt	4
Greece	4
Hong Kong	4
Iran, Islamic Republic of	4
United States\|Russian Federation	4
France\|Germany	3
Australia\|Canada	2
Croatia\|Czechia	2
Czech Republic	2
Czech Republic\|Germany	2
Israel\|Russian Federation	2
Lebanon	2
Malaysia	2
Netherlands\|Spain	2
Turkey	2
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|Chile\|Czech Republic\|Denmark\|Finland\|France\|Germany\|Greece\|Hong Kong\|Hungary\|Italy\|Malaysia\|Mexico\|Netherlands\|Norway\|Poland\|Portugal\|Singapore\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|United Kingdom	2
United States\|Belgium\|Netherlands	2
United States\|Canada\|Korea, Republic of	2
United States\|Germany	2
United States\|Italy	2
United States\|Netherlands	2
Argentina\|Australia\|Belgium\|Croatia\|France\|Germany\|Italy\|Netherlands\|Norway	1
Argentina\|Brazil\|China\|India\|Romania	1
Australia\|Austria\|Belgium\|Canada\|France\|Germany	1
Australia\|Austria\|Belgium\|Netherlands\|Russian Federation\|Slovakia\|United Kingdom	1
Australia\|Austria\|Denmark\|Germany\|New Zealand\|Spain\|Switzerland	1
Australia\|Austria\|Estonia\|Finland\|France\|Germany\|Israel\|Italy\|Korea, Republic of\|Mexico\|Netherlands\|Portugal\|Spain\|Switzerland\|Taiwan\|United Kingdom	1
Australia\|Austria\|Germany\|Hungary\|Netherlands\|Poland\|Russian Federation\|United Kingdom	1
Australia\|Austria\|United States\|Argentina\|Belgium\|Canada\|Chile\|China\|Czech Republic\|Estonia\|Finland\|France\|Germany\|Italy\|Korea, Republic of\|Mexico\|Morocco\|Netherlands\|Poland\|Russian Federation\|Sweden\|Tunisia\|Turkey	1
Australia\|Belgium\|Bulgaria\|Croatia\|Czech Republic\|Denmark\|Estonia\|Germany\|Hungary\|Lithuania\|Netherlands\|New Zealand\|Poland\|Portugal\|Romania\|Russian Federation\|Serbia\|Singapore\|Slovakia\|South Africa\|Spain\|Sweden\|Switzerland\|Ukraine	1
Australia\|Canada\|China\|Germany\|Israel	1
Australia\|Canada\|Czech Republic\|Denmark\|Estonia\|Finland\|France\|Germany\|Latvia\|Lithuania\|Netherlands\|Poland\|Serbia\|Slovakia\|Sweden\|Ukraine	1
Australia\|France\|Germany\|Hong Kong\|Italy	1
Australia\|France\|Germany\|Italy\|Portugal\|United Kingdom	1
Australia\|Germany\|Malaysia\|New Zealand\|United Kingdom	1
Australia\|Hong Kong\|Singapore	1
Austria\|Belgium\|Canada\|Czech Republic\|Germany\|Netherlands\|Russian Federation\|Slovakia	1
Austria\|Belgium\|Canada\|Czechia\|France\|Hungary\|Italy\|Japan\|Latvia\|Netherlands\|Spain\|Sweden\|Switzerland\|United Kingdom	1
Austria\|Belgium\|Czechia\|Italy	1
Austria\|Belgium\|Denmark\|France\|Germany\|Italy\|Spain\|Switzerland	1
Austria\|Belgium\|Denmark\|France\|Ireland\|Italy\|Netherlands\|Switzerland\|United Kingdom	1
Austria\|Belgium\|Finland\|Germany\|Greece\|Ireland\|Israel\|Japan\|Norway\|Switzerland\|United Kingdom	1
Austria\|Belgium\|France\|Germany\|Hungary\|Italy\|Korea, Republic of\|Lithuania\|Netherlands\|Poland\|Portugal\|Romania\|Serbia\|Spain\|Switzerland\|Taiwan\|Ukraine\|United Kingdom	1
Austria\|Czechia\|France\|Germany\|Italy\|Portugal\|Spain	1
Austria\|Germany\|Netherlands	1
Belgium\|Bulgaria\|Croatia\|Czechia\|Denmark\|Estonia\|Hungary\|Latvia\|Lithuania\|Poland\|Russian Federation\|Serbia\|Slovakia\|Spain\|Ukraine	1
Belgium\|Canada\|Czechia\|Germany\|Netherlands\|United Kingdom	1
Belgium\|Canada\|Czechia\|United Kingdom	1
Belgium\|Canada\|Denmark\|France\|Italy\|Spain\|Sweden	1
Belgium\|Canada\|Germany\|Italy\|Netherlands	1
Belgium\|Czech Republic\|Denmark\|Finland\|France\|Germany\|Hungary\|Italy\|Netherlands\|Poland\|Spain\|United Kingdom	1
Belgium\|Czech Republic\|France\|Italy\|Netherlands\|Poland\|Spain\|Sweden\|Switzerland	1
Belgium\|Czechia\|Denmark\|France\|Germany\|Italy	1
Belgium\|Czechia\|Denmark\|France\|Germany\|Italy\|Netherlands\|Poland\|Spain\|Switzerland\|United Kingdom	1
Belgium\|Czechia\|Denmark\|Italy	1
Belgium\|Czechia\|Germany\|Greece\|Hungary\|Israel\|Spain	1
Belgium\|Czechia\|Germany\|United Kingdom	1
Belgium\|Czechia\|Netherlands	1
Belgium\|France\|Germany\|Hungary\|Italy\|Netherlands\|Poland\|Russian Federation\|Spain	1
Belgium\|France\|Germany\|Hungary\|Netherlands\|United Kingdom	1
Belgium\|France\|Germany\|United Kingdom	1
Belgium\|Netherlands	1
Brazil\|Canada\|Sweden\|Taiwan	1
Brazil\|China\|Germany\|United States\|Argentina\|Australia\|Austria\|Belgium\|Bulgaria\|Canada\|Chile\|Colombia\|Czech Republic\|Denmark\|Finland\|France\|Greece\|Hong Kong\|Hungary\|India\|Israel\|Korea, Republic of\|Lithuania\|Malaysia\|Mexico\|Netherlands\|New Zealand\|Norway\|Peru\|Philippines\|Poland\|Romania\|Russian Federation\|Singapore\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey\|Ukraine\|United Kingdom\|Venezuela	1
Bulgaria	1
Bulgaria\|Czechia\|Hungary\|Ukraine	1
Bulgaria\|France\|Germany\|Poland\|Russian Federation\|Turkey\|Ukraine	1
Canada\|Czechia\|Germany\|Italy\|Netherlands\|United Kingdom	1
Canada\|Germany	1
Canada\|Germany\|United Kingdom	1
Canada\|Italy\|Norway\|Spain	1
Canada\|United States	1
Chile\|China\|Germany\|Italy\|Poland\|Portugal\|Thailand\|Turkey\|Ukraine\|Argentina\|United States\|Australia\|Belgium\|Brazil\|Bulgaria\|Canada\|Colombia\|Croatia\|Czechia\|Denmark\|Estonia\|Finland\|France\|Greece\|Guatemala\|Hungary\|India\|Israel\|Japan\|Korea, Republic of\|Mexico\|Netherlands\|New Zealand\|Norway\|Peru\|Philippines\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|United Kingdom	1
Chile\|Czechia\|United States\|Argentina\|Australia\|Belgium\|Brazil\|Bulgaria\|Canada\|Denmark\|France\|Germany\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|Poland\|Romania\|Russian Federation\|South Africa\|Sweden\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
China\|Korea, Republic of\|Singapore\|Taiwan	1
Colombia\|Czech Republic\|Denmark\|France\|Germany\|Mexico\|Spain	1
Croatia	1
Croatia\|Netherlands\|New Zealand	1
Cyprus\|Greece\|Israel	1
Czech Republic\|Denmark\|Hungary\|Netherlands\|Norway\|Poland\|Slovakia\|Sweden	1
Czech Republic\|France\|Italy\|Netherlands\|Serbia\|Slovakia\|United Kingdom	1
Czech Republic\|Germany\|Spain	1
Czechia\|France\|Germany\|Hungary\|Italy\|Netherlands\|Spain\|Switzerland	1
Czechia\|Germany	1
Czechia\|Germany\|Netherlands\|Poland\|United Kingdom	1
Czechia\|Hungary\|Italy\|Poland\|Spain	1
Czechia\|Italy\|United Kingdom	1
Czechia\|Japan	1
Denmark\|Finland\|Germany\|Hungary\|Netherlands\|Norway\|Poland\|Sweden	1
Denmark\|Finland\|Norway\|Sweden	1
Denmark\|Germany\|Netherlands\|Switzerland	1
Denmark\|Netherlands	1
Denmark\|Norway\|Poland\|Russian Federation\|Slovakia\|Sweden	1
Denmark\|Norway\|Poland\|Russian Federation\|Sweden\|United Kingdom	1
Denmark\|Norway\|Sweden	1
Denmark\|Russian Federation\|Sweden	1
Denmark\|Spain	1
Denmark\|United States\|Canada\|Sweden	1
Denmark\|United States\|Sweden	1
France\|Australia\|Austria\|Bulgaria\|Czech Republic\|Estonia\|Germany\|Hungary\|India\|Israel\|Japan\|Korea, Republic of\|Malaysia\|Netherlands\|Philippines\|Poland\|Russian Federation\|Slovakia\|South Africa\|Spain\|Thailand\|Ukraine\|United Kingdom	1
France\|Belgium\|Germany\|Italy\|Spain\|Switzerland\|United Kingdom	1
France\|Germany\|Greece	1
France\|Germany\|Spain\|United Kingdom	1
France\|Japan\|Netherlands	1
France\|United States\|Australia\|Canada\|Denmark\|Italy\|Netherlands\|New Zealand\|Poland\|United Kingdom	1
France\|United States\|Switzerland	1
Germany\|Greece\|Netherlands\|Poland\|Serbia\|Switzerland\|United Kingdom	1
Germany\|Hungary\|Spain	1
Germany\|Italy\|Spain\|United Kingdom	1
Germany\|Italy\|Sweden	1
Germany\|Spain\|United Kingdom	1
Germany\|Switzerland	1
Germany\|United Kingdom	1
Germany\|United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Croatia\|Czechia\|Denmark\|Finland\|France\|Greece\|Hong Kong\|Hungary\|India\|Ireland\|Israel\|Italy\|Japan\|Korea, Republic of\|Mexico\|Netherlands\|New Zealand\|Norway\|Poland\|Portugal\|Russian Federation\|Singapore\|Slovakia\|Slovenia\|Spain\|Sweden\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
Greece\|Netherlands	1
Greece\|Russian Federation	1
Hungary\|Netherlands	1
India	1
Ireland	1
Israel\|United States\|Belgium\|Canada\|Denmark\|Germany\|Italy\|Japan\|Korea, Republic of\|Romania\|Spain\|Sweden	1
Italy\|Switzerland	1
Italy\|United Kingdom	1
Mexico	1
Netherlands\|Belgium	1
Netherlands\|Switzerland\|United Kingdom	1
Netherlands\|United Kingdom	1
New Zealand\|Singapore\|Australia\|Hong Kong\|Japan\|Korea, Republic of\|Malaysia\|South Africa\|Taiwan\|Thailand	1
Nigeria	1
Poland\|United States\|Germany\|Israel\|Italy\|Netherlands\|United Kingdom	1
Romania	1
Romania\|Bulgaria\|United States\|Austria\|Belgium\|Czechia\|Denmark\|France\|Germany\|Hungary\|Israel\|Italy\|Netherlands\|Poland\|Russian Federation\|Spain\|Sweden\|Ukraine\|United Kingdom	1
Singapore	1
South Africa	1
Spain\|Switzerland\|Japan\|Netherlands\|Norway\|United States\|Austria\|Denmark\|Germany\|Greece\|Italy\|United Kingdom	1
Spain\|United States\|Canada\|China	1
Sweden\|United Kingdom	1
Taiwan\|Belgium\|Canada\|Czechia\|Germany\|Hungary\|Italy\|Korea, Republic of\|Poland\|Spain\|United Kingdom	1
Tunisia	1
United Kingdom\|United States\|Belgium\|Canada\|France\|Germany\|Italy\|Japan\|Netherlands\|Russian Federation\|Spain	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Croatia\|Czechia\|Denmark\|France\|Germany\|Hungary\|India\|Israel\|Italy\|Korea, Republic of\|Mexico\|Netherlands\|Norway\|Peru\|Poland\|Portugal\|Puerto Rico\|Romania\|Russian Federation\|Serbia\|Slovakia\|Spain\|Sweden\|Switzerland\|Ukraine\|United Kingdom\|Virgin Islands (U.S.)	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|China\|Colombia\|Czechia\|Denmark\|Finland\|France\|Germany\|Greece\|Hong Kong\|Hungary\|India\|Israel\|Italy\|Japan\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|Norway\|Peru\|Philippines\|Poland\|Portugal\|Romania\|Russian Federation\|Singapore\|Slovakia\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|Chile\|China\|Colombia\|Czechia\|Denmark\|Finland\|France\|Germany\|Greece\|Hong Kong\|India\|Indonesia\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Norway\|Philippines\|Poland\|Russian Federation\|Singapore\|South Africa\|Spain\|Sweden\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|Chile\|China\|Colombia\|Czechia\|Denmark\|Finland\|France\|Germany\|Hong Kong\|Hungary\|India\|Israel\|Italy\|Japan\|Korea, Republic of\|Malaysia\|Mexico\|Netherlands\|Norway\|Peru\|Philippines\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Singapore\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Canada\|Chile\|China\|Czech Republic\|Finland\|Germany\|Greece\|Hong Kong\|Hungary\|India\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Morocco\|Netherlands\|New Zealand\|Norway\|Philippines\|Poland\|Portugal\|Russian Federation\|Singapore\|South Africa\|Spain\|Sweden\|Taiwan\|Thailand\|Tunisia\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Canada\|Chile\|Denmark\|France\|Germany\|Hungary\|Italy\|Japan\|Netherlands\|Poland\|Russian Federation\|Spain\|Sweden\|Switzerland	1
United States\|Argentina\|Australia\|Canada\|South Africa	1
United States\|Argentina\|Belgium\|Brazil\|Canada\|Denmark\|Estonia\|France\|Germany\|Greece\|Hungary\|India\|Italy\|Korea, Republic of\|Latvia\|Mexico\|Netherlands\|New Zealand\|Norway\|Romania\|Spain\|Sweden\|Taiwan\|Thailand\|United Kingdom	1
United States\|Argentina\|Canada\|Chile\|Denmark\|Mexico\|Sweden	1
United States\|Argentina\|Canada\|Denmark\|India\|Poland	1
United States\|Argentina\|Canada\|Denmark\|South Africa\|Sweden	1
United States\|Argentina\|Czech Republic\|Former Serbia and Montenegro\|Germany\|Israel\|Poland\|Romania\|Russian Federation\|Slovakia\|South Africa\|Ukraine\|United Kingdom	1
United States\|Australia	1
United States\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|China\|Czech Republic\|Denmark\|Finland\|France\|Germany\|Greece\|Hong Kong\|Hungary\|India\|Israel\|Italy\|Korea, Republic of\|Malaysia\|Netherlands\|Norway\|Philippines\|Poland\|Portugal\|Romania\|Russian Federation\|Singapore\|Slovakia\|Sweden\|Switzerland\|Taiwan\|Thailand\|United Kingdom	1
United States\|Australia\|Belgium\|France\|Germany\|Netherlands\|Spain	1
United States\|Australia\|Brazil\|Canada\|India\|Israel\|Latvia\|Lithuania\|Poland\|Russian Federation\|South Africa\|Ukraine\|United Kingdom	1
United States\|Australia\|Canada	1
United States\|Australia\|Canada\|China\|Czechia\|Germany\|Italy\|Korea, Republic of\|Russian Federation\|United Kingdom	1
United States\|Australia\|Canada\|Netherlands	1
United States\|Australia\|Czechia\|France\|Germany\|Portugal\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Germany\|Italy	1
United States\|Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Poland\|Spain\|Switzerland\|United Kingdom	1
United States\|Austria\|Belgium\|Denmark\|Germany\|Italy\|Netherlands\|Spain\|United Kingdom	1
United States\|Austria\|Canada\|Germany\|Italy\|Netherlands\|Spain\|Sweden\|United Kingdom	1
United States\|Austria\|Germany\|Italy\|Netherlands\|Slovenia\|Spain	1
United States\|Belarus\|Belgium\|Bosnia and Herzegovina\|Canada\|Chile\|Latvia\|Mexico\|Moldova, Republic of\|Russian Federation\|Slovakia\|Ukraine	1
United States\|Belgium\|Brazil\|Canada\|China\|Denmark\|Finland\|France\|Germany\|Greece\|Italy\|Netherlands\|Portugal\|Singapore\|South Africa\|Spain\|United Kingdom	1
United States\|Belgium\|Canada\|Czechia\|Denmark\|Germany\|Hungary\|Italy\|Netherlands\|Norway\|Spain\|Switzerland\|United Kingdom	1
United States\|Belgium\|France\|Germany\|United Kingdom	1
United States\|Belgium\|Germany	1
United States\|Belgium\|Germany\|Netherlands	1
United States\|Brazil\|Canada\|Czechia\|Italy	1
United States\|Bulgaria\|Germany\|Hungary\|Italy\|Poland	1
United States\|Canada\|Czech Republic\|France\|Germany\|Hungary\|Italy\|Netherlands\|Portugal	1
United States\|Canada\|Czechia\|France\|Italy	1
United States\|Canada\|Czechia\|Germany\|Italy	1
United States\|Canada\|Denmark\|Netherlands	1
United States\|Canada\|Germany	1
United States\|Canada\|Hungary\|Netherlands\|Poland\|Serbia	1
United States\|Canada\|Japan	1
United States\|Colombia	1
United States\|Czech Republic\|Germany	1
United States\|Czech Republic\|Poland\|Russian Federation\|Ukraine	1
United States\|Czechia\|France\|Italy	1
United States\|Czechia\|Germany	1
United States\|Czechia\|Russian Federation	1
United States\|Germany\|Netherlands	1
United States\|Greece\|Russian Federation	1
United States\|Hungary\|Italy\|Saudi Arabia\|Slovakia\|South Africa\|United Kingdom	1
United States\|Israel	1
United States\|Japan	1
United States\|Puerto Rico	1
United States\|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	626
2	77
3	40
4	29
5	14
6	16
7	16
8	10
9	9
10	14
11	8
12	13
13	5
14	3
15	11
16	6
17	6
18	9
19	7
20	6
21	5
22	5
23	7
24	5
25	4
26	5
27	1
28	5
29	2
30	5
31	3
32	2
33	1
34	2
35	1
36	2
37	2
38	5
39	2
40	4
41	1
44	3
49	2
51	1
53	1
54	2
55	1
57	1
58	2
60	1
62	1
64	1
67	2
75	1
81	1
82	1
84	1
87	1
91	1
97	1
100	1
101	1
103	2
111	1
113	1
114	1
116	1
118	1
127	1
129	1
130	1
132	1
152	1
165	2
170	1
178	2
200	1
223	1
230	2
233	1
356	1
421	1
503	1
567	1
626	1
959	1
984	1
1016	1
1113	1

Phase

Phase	Study_Count
N/A	608
Phase 4	173
Phase 3	145
Phase 2	86
Phase 1	17
Phase 2/Phase 3	12
Phase 1/Phase 2	7
Early Phase 1	4

Number of Arms

Number_of_Arms	Count_of_Studies
1	210
2	652
3	74
4	40
5	5
6	4
7	1
8	1
9	1
10	1
11	1
NA	62

Number of Updates

Count of Versions	Count of Studies
1	101
2	154
3	154
4	119
5	106
6	73
7	64
8	61
9	43
10	33
11	26
12	16
13	7
14	15
15	11
16	7
17	7
18	9
19	4
20	1
21	2
22	3
24	1
25	3
26	1
27	2
28	1
29	1
30	2
32	1
33	1
34	1
36	1
37	3
38	2
40	1
44	1
45	1
46	2
48	1
50	2
62	1
63	1
64	1
65	1
76	1
85	1
129	1
131	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	6049	951	6.360673
Contacts/Locations	3369	820	4.108537
Recruitment Status	1410	806	1.749380
None (earliest Version on record)	1052	1052	1.000000
Study Design	1007	642	1.568536
Outcome Measures	840	503	1.669980
Sponsor/Collaborators	590	378	1.560847
Arms	576	378	1.523810
Interventions	576	378	1.523810
Eligibility	536	369	1.452575
Study Identification	520	341	1.524927
Study Description	459	325	1.412308
Oversight	425	350	1.214286
References	195	138	1.413043
Conditions	181	138	1.311594
Results	176	176	1.000000
More Information	163	96	1.697917
IPDSharing	150	130	1.153846
Results Submission Events	68	68	1.000000
Documents	51	45	1.133333
Baseline Characteristics	46	38	1.210526
Participant Flow	37	32	1.156250
Reported Adverse Events	33	26	1.269231
2020 Study Status	2	2	1.000000
Quality Control Review has not concludedReturned: June 24	1	1	1.000000
Quality Control Review has not concludedReturned: March 16	1	1	1.000000

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	10.0	1.000	13.00000	13.0	3.0000	48.0000	5.000	10.0000
1st Qu.	17.5	60.000	20.00000	23.0	50.0000	60.0000	120.000	80.0000
Median	30.0	122.000	40.00000	50.0	130.0000	205.0000	253.500	176.0000
Mean	30.0	4314.135	60.94118	62.0	220.7882	280.8333	1368.907	768.4566
3rd Qu.	42.5	300.000	58.00000	97.5	234.0000	431.0000	659.250	398.0000
Max.	50.0	1260576.000	280.00000	130.0	1280.0000	800.0000	21105.000	52000.0000

Trial Group Type

group_type	Group_Count
Experimental	874
Active Comparator	711
No Intervention	146
Other	145
Placebo Comparator	107
NA	62
Sham Comparator	7

Intervention Model

intervention_model	Study_Count
Parallel Assignment	754
Single Group Assignment	247
Crossover Assignment	30
Factorial Assignment	11
Sequential Assignment	5
NA	5

Primary Purpose

primary_purpose	Study_Count
Treatment	636
Prevention	199
Diagnostic	83
Other	37
Health Services Research	21
Screening	21
Supportive Care	21
NA	14
Basic Science	12
Device Feasibility	7
Educational/Counseling/Training	1

Observational Studies

Studies by Country

Country	Study_Count
United States	112
NA	50
France	36
Germany	35
Spain	22
United Kingdom	22
Korea, Republic of	17
Canada	16
China	16
Sweden	15
Finland	13
Italy	11
Japan	11
Switzerland	10
Netherlands	8
Denmark	7
Greece	6
Norway	6
Belgium	5
Russian Federation	5
Taiwan	5
Turkey	5
Poland	4
Austria	3
Germany\|Netherlands	3
Germany\|Switzerland	3
Israel	3
Thailand	3
Argentina	2
Korea, Republic of\|Taiwan	2
United States\|Puerto Rico	2
Argentina\|Azerbaijan\|Bahrain\|Chile\|Colombia\|Egypt\|Georgia\|Jordan\|Kazakhstan\|Kenya\|Lebanon\|Mexico\|Russian Federation\|Saudi Arabia\|United Arab Emirates\|Uruguay\|Venezuela	1
Argentina\|Canada\|Chile\|Germany\|Italy\|Spain	1
Australia	1
Australia\|Austria\|France\|Italy\|Portugal\|South Africa	1
Australia\|Belgium\|Canada\|France\|Germany\|Italy\|Monaco\|United Kingdom	1
Australia\|China\|Hong Kong\|Korea, Republic of\|Malaysia\|Philippines\|Taiwan\|Thailand	1
Austria\|Belarus\|Czech Republic\|Finland\|Germany\|Italy\|Netherlands\|Portugal\|Russian Federation\|Slovakia\|Slovenia\|Spain\|Sweden\|Switzerland\|United Arab Emirates\|United Kingdom	1
Austria\|Bulgaria\|Czechia\|Estonia\|Hungary\|Israel\|Latvia\|Poland\|Romania\|Russian Federation\|Serbia\|Slovenia	1
Austria\|Denmark\|Finland\|Germany\|Spain\|Sweden	1
Belgium\|Denmark\|Greece\|Netherlands\|Norway\|Portugal\|Sweden	1
Belgium\|Ireland\|Italy\|Netherlands\|Portugal\|Spain	1
Bulgaria\|Czech Republic\|Denmark\|France\|Germany\|Slovakia\|Spain\|United Kingdom	1
Bulgaria\|France\|Germany\|Poland\|Russian Federation\|Turkey\|Ukraine	1
Canada\|Netherlands	1
Canada\|Sweden	1
China\|Croatia\|Egypt\|Germany\|Lebanon\|Netherlands\|Spain\|Turkey	1
Colombia	1
Czech Republic\|United Kingdom	1
Czechia	1
Czechia\|France\|Germany\|Netherlands\|Spain\|Switzerland	1
Denmark\|France\|Germany\|Ireland\|Italy\|Netherlands\|Poland\|Spain\|United Kingdom	1
Denmark\|Germany\|Hong Kong\|Ireland\|Italy\|Poland\|Spain\|Sweden\|Thailand	1
Egypt	1
France\|Austria\|Belgium\|Bulgaria\|Croatia\|Czechia\|Denmark\|Estonia\|Germany\|Greece\|Ireland\|Italy\|Latvia\|Netherlands\|Norway\|Poland\|Portugal\|Romania\|Slovenia\|Spain\|Sweden\|United Kingdom	1
France\|Germany\|Hungary	1
France\|Italy\|Switzerland	1
Hong Kong	1
Hong Kong\|India\|Indonesia\|Korea, Republic of\|Malaysia\|Pakistan\|Philippines\|Singapore\|Taiwan\|Thailand\|Vietnam	1
Hong Kong\|India\|Korea, Republic of\|Singapore\|Taiwan\|Thailand	1
India	1
Indonesia\|Korea, Republic of\|Malaysia\|Singapore\|Thailand	1
Ireland	1
Jordan	1
Lithuania	1
Puerto Rico	1
Romania	1
Slovakia	1
Slovenia\|Sweden\|Austria\|Belgium\|Canada\|Czech Republic\|Denmark\|France\|Germany\|Hungary\|Ireland\|Israel\|Moldova, Republic of\|Netherlands\|Norway\|Poland\|Portugal\|Russian Federation\|Slovakia\|Ukraine\|United Kingdom	1
Tunisia	1
United States\|Argentina\|Brazil\|Canada\|Chile\|China\|Colombia\|Ecuador\|Hong Kong\|Japan\|Korea, Republic of\|Lebanon\|Mexico\|United Arab Emirates\|Peru\|Russian Federation\|Saudi Arabia\|Singapore\|South Africa\|Taiwan\|Venezuela	1
United States\|Australia\|Belgium\|France\|Germany\|Netherlands\|Spain	1
United States\|Australia\|Canada	1
United States\|Australia\|France	1
United States\|Belgium\|Canada\|Greece\|Netherlands	1
United States\|Canada	1
United States\|Germany\|Israel\|United Kingdom	1
United States\|Greece	1
United States\|Monaco	1
United States\|Netherlands	1
United States\|New Zealand	1
United States\|Puerto Rico\|Virgin Islands (U.S.)	1
Venezuela	1

Sites per Study

Site_count	Study_Count
1	376
2	33
3	15
4	11
5	5
6	6
7	4
8	6
9	6
10	1
11	1
12	1
13	4
15	1
16	1
17	2
18	1
19	2
21	3
22	3
23	1
24	2
26	1
27	1
28	1
29	1
32	1
39	1
40	1
42	1
45	1
47	1
50	1
55	1
56	1
62	1
75	1
100	1
140	1
148	1
161	1
171	1
220	1
523	1
666	1
1164	1
1616	1

Number of Updates

Count of Versions	Count of Studies
1	71
2	110
3	83
4	58
5	31
6	22
7	18
8	14
9	18
10	7
11	6
12	4
13	7
14	1
15	3
16	2
17	1
18	6
19	2
20	5
22	4
23	2
24	1
25	2
26	3
27	2
28	2
30	1
31	2
32	1
33	1
34	1
35	1
38	2
40	1
43	1
46	1
50	1
51	1
55	1
57	1
59	1
61	2
63	1
78	1
80	2
118	1
120	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	3313	439	7.546697
Contacts/Locations	1190	341	3.489736
Recruitment Status	554	357	1.551821
None (earliest Version on record)	510	510	1.000000
Study Design	423	283	1.494700
Outcome Measures	231	162	1.425926
Sponsor/Collaborators	155	119	1.302521
Study Identification	145	107	1.355140
Eligibility	143	115	1.243478
Study Description	134	106	1.264151
Oversight	108	98	1.102041
References	102	85	1.200000
Groups	91	77	1.181818
Interventions	91	77	1.181818
Conditions	52	46	1.130435
Results	52	52	1.000000
IPDSharing	48	40	1.200000
Documents	25	25	1.000000
Results Submission Events	25	25	1.000000
More Information	17	12	1.416667
Participant Flow	5	4	1.250000
Baseline Characteristics	3	2	1.500000
Reported Adverse Events	3	2	1.500000

Enrollment Metrics

Measure	Observational
Min	5.00
1st Qu	100.00
Median	364.00
Mean	13442.17
3rd Qu	1739.50
Max	814446.00

Observation Model

observational_model	Study_Count
Cohort	345
Case-Only	62
Case-Control	31
Other	27
Case Control	19
NA	19
Case-Crossover	3
Ecologic or Community	3
Defined Population, Natural History	1

Time Perspective

time_perspective	Study_Count
Prospective	336
Retrospective	128
Cross-Sectional	30
Other	9
NA	6
Longitudinal, Retrospective	1

Registries

Studies by Country

Country	Study_Count
United States	18
NA	11
Italy	10
Germany	8
Korea, Republic of	6
Canada	5
China	4
France	4
Egypt	3
Poland	3
Russian Federation	3
Spain	3
Finland	2
Netherlands	2
Singapore	2
Sweden	2
Switzerland	2
Australia\|Belgium\|Chile\|Denmark\|Finland\|France\|Germany\|Ireland\|Israel\|Italy\|Netherlands\|Norway\|Poland\|Spain\|Sweden\|United Kingdom	1
Australia\|Hong Kong\|Indonesia\|Korea, Republic of\|Malaysia\|Saudi Arabia\|Thailand	1
Austria	1
Austria\|Belgium\|Canada\|China\|Czechia\|France\|Germany\|India\|Italy\|Korea, Republic of\|Netherlands\|Portugal\|Saudi Arabia\|Spain\|United Kingdom	1
Austria\|Denmark\|Sweden	1
Austria\|Germany	1
Belgium	1
Belgium\|Austria\|France\|Germany\|Switzerland	1
Belgium\|France\|Germany\|Ireland\|Italy\|Netherlands\|Poland\|Portugal\|Russian Federation\|Saudi Arabia\|Spain\|United Arab Emirates\|United Kingdom	1
Belgium\|Netherlands	1
Brazil	1
China\|Hong Kong\|Japan\|Korea, Republic of\|Taiwan	1
Colombia	1
Czechia\|Germany\|Ireland\|Spain\|United Kingdom	1
Denmark	1
France\|Georgia\|Germany\|Greece\|Hungary\|Israel\|Italy\|Korea, Republic of\|Netherlands\|Poland\|Portugal\|Spain\|Switzerland\|United Kingdom	1
France\|United Kingdom	1
Greece	1
Indonesia	1
Israel	1
Japan	1
Latvia	1
Netherlands\|Russian Federation	1
Tunisia	1
Turkey	1
United Kingdom	1
United States\|Argentina\|Austria\|Belgium\|Brunei Darussalam\|Chile\|China\|Colombia\|Czechia\|Germany\|Greece\|Hungary\|Iceland\|Indonesia\|Italy\|Japan\|Kazakhstan\|Korea, Republic of\|Kuwait\|Malaysia\|Mexico\|Oman\|Philippines\|Poland\|Portugal\|Russian Federation\|Saudi Arabia\|Serbia\|Singapore\|Slovakia\|South Africa\|Spain\|Switzerland\|Taiwan\|Thailand\|United Arab Emirates\|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	81
2	7
3	2
4	3
9	4
12	1
13	1
15	1
16	1
20	1
21	2
25	1
41	1
47	1
51	1
62	2
90	1
91	1
98	1
125	1
154	1

Number of Updates

Count of Versions	Count of Studies
1	15
2	28
3	26
4	14
5	5
6	4
7	3
8	9
9	1
10	1
11	4
12	2
22	1
25	1
28	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	389	100	3.890000
Contacts/Locations	200	73	2.739726
None (earliest Version on record)	115	115	1.000000
Recruitment Status	103	68	1.514706
Study Description	62	37	1.675676
Study Design	61	45	1.355556
Outcome Measures	46	38	1.210526
Study Identification	32	27	1.185185
Sponsor/Collaborators	24	19	1.263158
Oversight	23	21	1.095238
Eligibility	21	19	1.105263
Groups	16	14	1.142857
Interventions	16	14	1.142857
Conditions	14	14	1.000000
IPDSharing	13	13	1.000000
References	10	6	1.666667
Documents	6	5	1.200000
Results	5	5	1.000000
Results Submission Events	5	5	1.000000
More Information	1	1	1.000000

Enrollment Metrics

Measure	Registries
Min	1.0
1st Qu	250.0
Median	910.0
Mean	118920.4
3rd Qu	2127.0
Max	7205000.0

Registry Model

observational_model	Study_Count
Cohort	84
Case-Only	16
Case-Control	6
Other	5
Ecologic or Community	2
Case-Crossover	1
NA	1

Time Perspective

time_perspective	Study_Count
Prospective	105
Other	5
Cross-Sectional	3
Retrospective	1
NA	1

Follow-up

target_duration	Study_Count
12 Months	22
1 Year	16
2 Years	14
5 Years	11
1 Day	8
3 Years	8
10 Years	5
24 Months	5
1 Month	4
18 Months	2
3 Months	2
30 Days	2
6 Months	2
105 Months	1
12 Weeks	1
15 Years	1
17 Years	1
2 Days	1
3 Days	1
36 Months	1
4 Months	1
4 Weeks	1
4 Years	1
60 Days	1
60 Months	1
8 Weeks	1
90 Days	1

Count of Versions	Count of Studies
1	101
2	154
3	154
4	119
5	106
6	73
7	64
8	61
9	43
10	33
11	26
12	16
13	7
14	15
15	11
16	7
17	7
18	9
19	4
20	1
21	2
22	3
24	1
25	3
26	1
27	2
28	1
29	1
30	2
32	1
33	1
34	1
36	1
37	3
38	2
40	1
44	1
45	1
46	2
48	1
50	2
62	1
63	1
64	1
65	1
76	1
85	1
129	1
131	1

Count of Versions	Count of Studies
1	71
2	110
3	83
4	58
5	31
6	22
7	18
8	14
9	18
10	7
11	6
12	4
13	7
14	1
15	3
16	2
17	1
18	6
19	2
20	5
22	4
23	2
24	1
25	2
26	3
27	2
28	2
30	1
31	2
32	1
33	1
34	1
35	1
38	2
40	1
43	1
46	1
50	1
51	1
55	1
57	1
59	1
61	2
63	1
78	1
80	2
118	1
120	1

Site_count	Study_Count
1	81
2	7
3	2
4	3
9	4
12	1
13	1
15	1
16	1
20	1
21	2
25	1
41	1
47	1
51	1
62	2
90	1
91	1
98	1
125	1
154	1

Count of Versions	Count of Studies
1	101
2	154
3	154
4	119
5	106
6	73
7	64
8	61
9	43
10	33
11	26
12	16
13	7
14	15
15	11
16	7
17	7
18	9
19	4
20	1
21	2
22	3
24	1
25	3
26	1
27	2
28	1
29	1
30	2
32	1
33	1
34	1
36	1
37	3
38	2
40	1
44	1
45	1
46	2
48	1
50	2
62	1
63	1
64	1
65	1
76	1
85	1
129	1
131	1

Count of Versions	Count of Studies
1	71
2	110
3	83
4	58
5	31
6	22
7	18
8	14
9	18
10	7
11	6
12	4
13	7
14	1
15	3
16	2
17	1
18	6
19	2
20	5
22	4
23	2
24	1
25	2
26	3
27	2
28	2
30	1
31	2
32	1
33	1
34	1
35	1
38	2
40	1
43	1
46	1
50	1
51	1
55	1
57	1
59	1
61	2
63	1
78	1
80	2
118	1
120	1

Site_count	Study_Count
1	81
2	7
3	2
4	3
9	4
12	1
13	1
15	1
16	1
20	1
21	2
25	1
41	1
47	1
51	1
62	2
90	1
91	1
98	1
125	1
154	1

atrial fibrillation

Study Counts

Studies over Time

Interventional Trials

Intervention Type

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Studies by Country

Sites per Study

Phase

Number of Arms

Number of Updates

Update History Change Type

Enrollment Metrics by Phase

Trial Group Type

Intervention Model

Primary Purpose

Observational Studies

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Observation Model

Time Perspective

Registries

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Registry Model

Time Perspective

Follow-up

Count of Versions	Count of Studies
1	101
2	154
3	154
4	119
5	106
6	73
7	64
8	61
9	43
10	33
11	26
12	16
13	7
14	15
15	11
16	7
17	7
18	9
19	4
20	1
21	2
22	3
24	1
25	3
26	1
27	2
28	1
29	1
30	2
32	1
33	1
34	1
36	1
37	3
38	2
40	1
44	1
45	1
46	2
48	1
50	2
62	1
63	1
64	1
65	1
76	1
85	1
129	1
131	1

Count of Versions	Count of Studies
1	71
2	110
3	83
4	58
5	31
6	22
7	18
8	14
9	18
10	7
11	6
12	4
13	7
14	1
15	3
16	2
17	1
18	6
19	2
20	5
22	4
23	2
24	1
25	2
26	3
27	2
28	2
30	1
31	2
32	1
33	1
34	1
35	1
38	2
40	1
43	1
46	1
50	1
51	1
55	1
57	1
59	1
61	2
63	1
78	1
80	2
118	1
120	1

Site_count	Study_Count
1	81
2	7
3	2
4	3
9	4
12	1
13	1
15	1
16	1
20	1
21	2
25	1
41	1
47	1
51	1
62	2
90	1
91	1
98	1
125	1
154	1